Electrospun Nanofibrous Composite Membranes for Long‐Term Release of Celecoxib for Achilles Tendon Reconstruction Following Injury

Embedding multiple pharmaceutical drugs into poly(lactic-co-glycolic acid) (PLGA) nanofibers is known to improve the regeneration of Achilles tendon upon implantation after injury and rapidly restore post-surgery activity. In this study, an implantable material comprising celecoxib, collagen, bupivacaine, PLGA (CCBP) prepared by electrospinning. Its in vitro/vivo drug discharge behaviors are evaluated, its efficacy investigated a rat model. The capacity wounded also compared with that doxycycline-collagen-bupivacaine-PLGA (DCBP) combination. results show that, relative primary nanofibers, pharmaceutical-embedded have thinner fiber diameters higher hydrophilicity. drug-eluting offer sustained release celecoxib for at least 30 d vitro 28 vivo. tendons regenerated using CCBP combination demonstrate significantly maximum load-to-failure than normal those repaired DCBP Additionally, expression growth factors composition collagen I induced superior suggest promising scaffold repair ruptured tendons.